The Pros and Cons of Metformin Diabetes

Metformin Diabetes is a compound that is classified under the biguanides group that is popularly used orally for treatment of Type 2 diabetes. The brand name for this drug is Glucophage, Glucophage XR, Riomet or Glumetza) and it is used to bring down levels of blood sugar by improved efficacy of the insulin in the body. The liver is prevented from producing excess amounts of glucose and the sensitivity of fat cells and muscle in the body are increased.

Metformin Diabetes works well to lower levels of blood glucose and preventing the risks of diabetic complications occurring long term. Apart from this, it aids in preventing weight gain by lowering triglyceride and blood cholesterol levels unlike other oral drugs used for lowering blood-glucose levels. Some of the main causes of type 2 diabetes patients’ deaths is mainly due to high cholesterol, obesity and increased levels of triglyceride. Metformin has the added advantage of preventing low levels of blood glucose causing hypoglycaemia when used as a drug for diabetes. This drug is generally prescribed twice a day to be consumed with meals. The Glucophage XR which contains the extended release properties should be taken once a day at supper time.

Side effects such as diarrhea, or nausea, which commonly occur with use of Metformin Diabetes, do not last for long periods. However, there is a possibility of contracting lactic acidosis, which is a potential condition that can prove fatal, when lactic acid develops at alarmingly high levels in the bloodstream. This dangerous side effect normally affects people who already suffer from a congestive heart failure, liver, kidney disease, or drink excessive amounts of alcohol. Metformin is not recommended if you are habituated to drinking at least four drinks of alcohol in a week.

Some doctors disregard this danger and fail to advise the patient of contraindications that make the treatment futile and prescribe the Metformin drug to people who are at risk for contracting lactic acidosis. Nausea, vomiting, muscle pain, fatigue, loss of appetite and difficulties with breathing are all symptoms connected with lactic acidosis. You should notify your doctor immediately if you experience any of the above symptoms when taking Metformin Diabetes medication. This therapy should ideally be stopped before surgery for at least 48 hours and resumed when the patient is able to eat normal food again.

Significant changes resulted in 1994 when Metformin Diabetes was approved by the U.S Food and Drug Administration. (FDA) At this particular time, only sulfonylureas, a type of oral drug administered to lower blood glucose (by increasing insulin secretion in the pancreas) and insulin were the only other two types of medication available for treating Type 2 diabetes in the U.S. Subsequently after the approval, several types of drugs for diabetes through different mechanisms were introduced. These are thiazolidinediones for increasing insulin sensitivity, inhibitors of alpha-glucosidase, which reduces the rate of carbohydrate absorption in the small intestines, thereby encouraging the blood sugar levels to rise slowly, after a meal is consumed and meglitinides, which uses a different type of mechanism to rapidly stimulate the secretion of insulin, after a meal, from the pancreatic regions. Other types of classified drugs include DAPP-4 inhibitors and GLP-1 agonists, both of which enable secretion of insulin, while slowing down the emptying of the stomach and analogs of amyline which also suppresses appetite and glucagon at the same time. Doctors should take care when combine the different medications to ensure that there are no adverse reaction when trying to lower the levels of blood sugar.


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